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KMID : 1161420130160040280
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Journal of Medicinal Food
2013 Volume.16 No. 4 p.280 ~ p.287
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Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation
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Hu Yuan
Liu Ming
Liu Ping
Yan Juan-Juan
Liu Ming-Yue
Zhang Gang-Qiang
Zhou Xiao-Jiang
Yu Bing-Ying
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Abstract
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The present study aimed to evaluate the effect of kai xin san (KXS, at doses of 500, 250, and 125?mg/kg body weight per day), a well-known traditional Chinese medicine, on learning and memory in paradoxical sleep deprivation (PSD)-induced cognition deficit rats. Two behavior tests (the Open Field test and the Morris water maze task) were used for testing the effects of KXS on a PSD-induced learning and memory deficit model. Furthermore, its effect on the glutamic acid (GLU) and γ-amino-butyric acid (GABA) levels in the brain tissue, brain-derived neurotrophic factor (BDNF), cyclic AMP response element binding protein (CREB), and phosphorylated-CREB (p-CREB) expression in the hippocampus was also tested. KXS exerted the greatest cognition against the 48?h PSD-induced cognitive deficit and these effects may be mediated by decreasing the GLU and GABA levels and increasing the levels of BDNF, CREB, and p-CREB. This study indicates that the effect of KXS on learning and memory in a rat model of PSD could be associated with the modulation of neurotransmitter levels and the expression of some genes in the brain that contribute to memory functions.
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KEYWORD
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kai xin san, learning and memory, paradoxical sleep deprivation
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